AMLODIPINE BASE
Amlodipine
CAS: 88150-42-9
Molecular Formula: C20H25ClN2O5
AMLODIPINE BASE - Names and Identifiers
| Name | Amlodipine |
| Synonyms | LOTREL Amlodipine AMLODIPINE amlodipine AMLODIPINE BASE 3-ethyl5-methylester (R)-3-ethyl 5-methyl 2 Amlodipine base (crystalline) 3,5-pyridinedicarboxylicacid,1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor Methyl ethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methyl ethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| CAS | 88150-42-9 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3 |
AMLODIPINE BASE - Physico-chemical Properties
| Molecular Formula | C20H25ClN2O5 |
| Molar Mass | 408.88 |
| Density | 1.227±0.06 g/cm3(Predicted) |
| Melting Point | 178-179°C |
| Boling Point | 527.2±50.0 °C(Predicted) |
| Water Solubility | 75.3 mg/L |
| Solubility | 75.3 mg/L |
| Appearance | Yellow solid |
| Color | White |
| pKa | pKa 8.6 (Uncertain) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months. |
| MDL | MFCD00887594 |
| Physical and Chemical Properties | Amlodipine Maleate: C20H25CIN2O5? C4H4O4. [88150-47-4]. White crystals were obtained from ethyl acetate, melting point 178-179 °c. |
AMLODIPINE BASE - Risk and Safety
| RTECS | US7968329 |
| Hazard Class | 6.1 |
| Toxicity | TDLo orl-chd: 400 mg/kg:BPR AJEMEN 18,581,2000 |
AMLODIPINE BASE - Reference
| Reference Show more | 1. [IF=3.535] Hui Jiang et al."Determination of lipid–water partition coefficient of neutral and ionic drugs by liposome electrokinetic chromatography."Electrophoresis. 2021 Aug;42(14-15):1436-1449 |
AMLODIPINE BASE - Nature
Open Data Verified Data
white crystalline powder.
Last Update：2024-01-02 23:10:35
AMLODIPINE BASE - Preparation Method
Open Data Verified Data
ethyl chloroacetoacetate, N-benzylaminoethanol and sodium hydride were reacted in tetrahydrofuran to give ethyl 4-(2-benzylaminoethoxy) acetoacetate. Then it reacts with O-chlorobenzaldehyde, 3-amino methyl methacrylate and acetic acid in methanol, and the resulting product is hydrogenated and reduced to obtain amlodipine. Alternatively, ethyl chloroacetoacetate and ammonium azide ethanol are condensed under the action of sodium hydride to obtain ethyl 4-(2-azidoethoxy) acetoacetate, which is then cyclized with O-chlorobenzaldehyde and methyl 3-aminobutenoate, the final reduction of the azido group gave amlodipine.
Last Update：2025-06-10 22:55:16
AMLODIPINE BASE - Application
Open Data Verified Data
developed by Pfizer Inc., USA, launched in 1990. Long-acting dihydropyridine calcium antagonists. For hypertension, can be used alone or in combination with other antihypertensive drugs, can also be used in patients with stable angina.
Last Update：2025-08-19 16:24:40
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